Members

Thibault Helleputte

Contact Information

Thibault Helleputte
PhD
DNAlytics
Rue Louis de Geer 6
1348 Louvain-la-Neuve
Belgium

Office: CEI2
Phone: +32 10 39 00 96
Email: thibault [period] helleputte [snail] dnalytics [period] com -> mailto:thibault [period] helleputte [snail] dnalytics [period] com
Personal home page

Biography

Thibault Helleputte

Thibault Helleputte holds a M.S. in Computing Science Engineering and a Ph.D. in Engineering Sciences from the University of Louvain. He also holds a Master of Management Sciences from the Louvain School of Management. His research work during his Ph.D. was centered on Machine Learning applied to the design of novel tools for automated prediction based on genomic technology. Those tools can be used for diagnosis, prognosis, treatment response prediction, and gene profiling. Thibault Helleputte is co-founder and CEO of DNAlytics.



Publications

Article de périodique (Journal article)
2015
  • Lauwerys, Bernard ; Hernández-Lobato, Daniel ; Gramme, Pierre ; Ducreux, Julie ; Dessy, Adrien ; Focant, Isabelle ; Ambroise, Jérôme ; Bearzatto, Bertrand ; Nzeusseu Toukap, Adrien ; Van den Eynde, Benoît ; Elewaut, Dirk ; Gala, Jean-Luc ; Durez, Patrick ; Houssiau, Frédéric ; Helleputte, Thibault ; Dupont, Pierre. Heterogeneity of synovial molecular patterns in patients with arthritis. In: PLoS One, Vol. 10, no. 4, p. e0122104 [1-18] (2015). doi:10.1371/journal.pone.0122104. http://hdl.handle.net/2078.1/162746

  • 2014
  • Boidot, Romain ; Branders, Samuel ; Helleputte, Thibault ; Illan Rubio, Laila ; Dupont, Pierre ; Feron, Olivier. A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.. In: OncoTarget, Vol. 5, no.16, p. 6947-63 (2014). http://hdl.handle.net/2078.1/151247

  • 2013
  • Wanty, Catherine ; Helleputte, Thibault ; Smets, Françoise ; Sokal, Etienne ; Stéphenne, Xavier. Assessment of risk of bleeding from esophageal varices during management of biliary atresia in children. In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 56, no. 5, p. 537-543 (2013). doi:10.1097/MPG.0b013e318282a22c. http://hdl.handle.net/2078.1/143932

  • 2012
  • Helleputte, Thibault. Strategic overview of personalised medicine. In: International Pharmaceutical Industry, Vol. 4, no. 2, p. 58-62 (2012). http://hdl.handle.net/2078.1/112689

  • 2010
  • Abeel, Thomas ; Helleputte, Thibault ; Van de Peer, Yves ; Dupont, Pierre ; Saeys, Yvan. Robust biomarker identification for cancer diagnosis with ensemble feature selection methods. In: Bioinformatics, Vol. 26, no. 3, p. 392-398 (2010). doi:10.1093/bioinformatics/btp630. http://hdl.handle.net/2078.1/34206

  • Brevet (Patent)
    2015
  • Feron, Olivier ; Dupont, Pierre ; Boidot, Romain ; Branders, Samuel ; Helleputte, Thibault. Signature of cycling hypoxia and use thereof for the prognosis of cancer. Numéro de priorité ; Déposé (01/08/2014) ; Publié (01/08/2015). . http://hdl.handle.net/2078.1/157278

  • 2010
  • Dupont, Pierre ; Gaulis, Swann ; Helleputte, Thibault. Method for classifying a cancer patient as responder or non-responder to immunotherapy. Numéro de priorité ; Déposé (2010-03-18) ; Publié (2010-03-18). AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).. http://hdl.handle.net/2078.1/108059

  • Communication à un colloque (Conference Paper)
    2016
  • Stéphenne, Xavier ; Bonnet, Nicolas ; Varma, Sharat ; Helleputte, Thibault ; Smets, Françoise ; Veyckemans, Francis ; Eeckhoudt, Stéphane ; Hermans, Cédric ; Sokal, Etienne. Evaluating risk of esophageal variceal bleed in children with cirrhosis and waitlisted for liver transplantation. 49th Annual Meeting of ESPGHAN (European Society for Paediatric Gastroenterology Hepatology and Nutrition) (Athènes, Grèce, du 25/05/2016 au 28/05/2016). In: Journal of Pediatric Gastroenterology and Nutrition, (2016). http://hdl.handle.net/2078.1/171897

  • 2010
  • Hernandez-Lobato, Daniel ; Hernández-Lobato, José Miguel ; Helleputte, Thibault ; Dupont, Pierre. Expectation Propagation for Bayesian Multi-task Feature Selection. Machine Learning and Knowledge Discovery in Databases. European Conference, ECML PKDD 2010 (Barcelona, Spain, du 20/09/2010 au 24/09/2010). In: Machine Learning and Knowledge Discovery in Databases. European Conference, ECML PKDD 2010 (Lecture notes in artificial intellgience; 6321), Springer: (Germany) Heidelberg, 2010. 978-3-642-15879-7, 522-537. http://hdl.handle.net/2078.1/67341

  • 2009
  • Helleputte, Thibault ; Dupont, Pierre. Biomarker selection by transfer learning with linear regularized models. Third International Workshop on Machine Learning in Systems Biology (MLSB) (Ljubljana, Slovenia, du 05/09/2009 au 06/09/2009). http://hdl.handle.net/2078.1/108041

  • Helleputte, Thibault ; Dupont, Pierre. Feature selection by transfer learning with linear regularized models. Machine Learning and Knowledge Discovery in Databases. European Conference, ECML PKDD 2009 (Bled, Slovenia, 7-11 September 2009). In: Machine Learning and Knowledge Discovery in Databases. European Conference, ECML PKDD 2009 (Lecture notes in artificial intelligence; 5781), Springer-verlag, 2009. 978-3-642-04179-2, p. 533-547. http://hdl.handle.net/2078.1/67479

  • Helleputte, Thibault ; Dupont, Pierre. Partially supervised feature selection with regularized linear models. ICML '09 : 26th Annual International Conference on Machine Learning (Montréal, Canada, du 14/06/2009 au 18/06/2009). In: ICML '09 Proceedings of the 26th Annual International Conference on Machine Learning, ACM: Montreal,Canada, 2009. 978-1-60558-516-1, p. 409-416. http://hdl.handle.net/2078.1/87501

  • Abeel, Thomas ; Helleputte, Thibault ; Van de Peer, Yves ; Dupont, Pierre ; Saeys, Yvan. Robust biomarker identification for cancer diagnosis using ensemble feature selection methods. Third International Workshop on Machine Learning in Systems Biology (MLSB) (Ljubljana, Slovenia, du 05/09/2009 au 06/09/2009). http://hdl.handle.net/2078.1/87502

  • 2008
  • Louahed, Jamila ; Dréno, B. ; Gaulis, Swann ; Helleputte, Thibault ; Dupont, Pierre ; Gruselle, Olivier ; Spatz, A. ; Kruit, W. ; Lehmann, F. ; Brichard, Vincent. Clinical response to the MAGE-A3 immunotherapeutic in metastatic melanoma patients is associated with a specific gene profile present prior to treatment. European society for medical oncology (Stockholm, du 12/09/2008 au 16/09/2008). In: Annals of Oncology, Vol. 19, no. Sppl. 8, p. VIII61-VIII62 (2008). http://hdl.handle.net/2078.1/107830

  • 2007
  • Helleputte, Thibault ; Dupont, Pierre. A comparative study of normalization and feature selection techniques for breast cancer prognosis from gene expressions. Benelux Bioinformatics conference (BBC'07) (Leuven, Belgiqum, du 12/11/2007 au 13/11/2007). http://hdl.handle.net/2078.1/107827

  • Thèse (Dissertation)
    2010
  • Helleputte, Thibault. Inductive biases for stable feature selection in high dimensional spaces : applications to gene profiling and diagnosis from DNA microarrays, prom. : Dupont, Pierre ; Sokal, Etienne, 07/09/2010. http://hdl.handle.net/2078.1/33278